Maps & Directions

Below are directions and a map to help you find the Avera Cancer Institute. If you have any questions concerning directions or parking, please call us at (605) 322-3000.

Avera Cancer Institute address:
1000 E. 21st Street
Sioux Falls, SD 57105

We are located on the Avera McKennan Hospital & University Health Center campus. The campus is on the west side of Cliff Ave between 10th St. and 26th St. Free valet parking is available at the Avera Cancer Institute entrance. Our valets are located just in side the entrance.

• View a printable Sioux Falls map showing our location »
• View our Avera Cancer Institute brochure. This printable piece has detailed driving instructions, specific directions for each clinic inside the Avera Cancer Institute and parking information.